Synthesis of progesterone in Schwann cells: regulation by sensory neurons.

  title={Synthesis of progesterone in Schwann cells: regulation by sensory neurons.},
  author={Françoise Robert and Rachida Guennoun and Frank Desarnaud and A Do-Thi and Yasmina Benmessahel and Etienne Emile Baulieu and Michael Schumacher},
  journal={The European journal of neuroscience},
  volume={13 5},
In peripheral nerves, progesterone synthesized by Schwann cells has been implicated in myelination. In spite of such an important function, little is known of the regulation of progesterone biosynthesis in the nervous system. We show here that in rat Schwann cells, expression of the 3 beta-hydroxysteroid dehydrogenase and formation of progesterone are dependent on neuronal signal. Levels of 3 beta-hydroxysteroid dehydrogenase mRNA and synthesis of [3H]progesterone from [3H]pregnenolone were low… CONTINUE READING


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