Synthesis of potent agonists of the D-myo-inositol 1,4, 5-trisphosphate receptor based on clustered disaccharide polyphosphate analogues of adenophostin A.

@article{Kort2000SynthesisOP,
  title={Synthesis of potent agonists of the D-myo-inositol 1,4, 5-trisphosphate receptor based on clustered disaccharide polyphosphate analogues of adenophostin A.},
  author={M. de Kort and V. Corr{\^e}a and A. Valentijn and G. A. van der Marel and B. Potter and C. Taylor and J. V. van Boom},
  journal={Journal of medicinal chemistry},
  year={2000},
  volume={43 17},
  pages={
          3295-303
        }
}
  • M. de Kort, V. Corrêa, +4 authors J. V. van Boom
  • Published 2000
  • Chemistry, Medicine
  • Journal of medicinal chemistry
    • Clustered disaccharide analogues of adenophostin A (2), i.e. mono-, di-, and tetravalent derivatives 6-8, respectively, were synthesized and evaluated as novel ligands for the tetrameric D-myo-inositol 1,4, 5-trisphosphate receptor (IP(3)R). The synthesis was accomplished via Sonogashira coupling of propargyl 2-O-acetyl-5-O-benzyl-3-O-(3, 4-di-O-acetyl-2, 6-di-O-benzyl-alpha-D-glucopyranosyl)-beta-D-ribofuranoside (16) with iodobenzene 18, 22, or 25, followed by deacetylation, phosphorylation… CONTINUE READING
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