Synthesis of polysubstituted dihydropyridines by four-component reactions of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate.

@article{Sun2010SynthesisOP,
  title={Synthesis of polysubstituted dihydropyridines by four-component reactions of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate.},
  author={Jing Sun and Er-Yan Xia and Qun Wu and Chao-Guo Yan},
  journal={Organic letters},
  year={2010},
  volume={12 16},
  pages={3678-81}
}
A practical and efficient procedure for the preparation of the polysubstituted dihydropyridines was developed through a unique four-component reaction of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate in ethanol in the presence of triethylamine as a base promoter. This four-component reaction is atom-efficient, high-yielding, and… CONTINUE READING