Synthesis of polybrominated benzimidazole and benzotriazole derivatives containing a tetrazole ring and their cytotoxic activity

@inproceedings{ukowskaChojnacka2016SynthesisOP,
  title={Synthesis of polybrominated benzimidazole and benzotriazole derivatives containing a tetrazole ring and their cytotoxic activity},
  author={Edyta Łukowska-Chojnacka and Patrycja Wińska and Monika Wielechowska and Maria Bretner},
  booktitle={Monatshefte fur chemie},
  year={2016}
}
ABSTRACT A series of new benzimidazole and benzotriazole derivatives containing a tetrazole moiety was synthesized by N-alkylation of 5-aryltetrazole with 4,5,6,7-tetrabromo-1-(3-chloropropyl)-1H-benzimidazole and 4,5,6,7-tetrabromo-2-(3-chloropropyl)-2H-benzotriazole. The reaction was regioselective and mostly 2,5-disubstituted tetrazole derivatives were… CONTINUE READING