Synthesis of polyallylamine derivatives and their use as gene transfer vectors in vitro.

@article{Boussif1999SynthesisOP,
  title={Synthesis of polyallylamine derivatives and their use as gene transfer vectors in vitro.},
  author={Otmane Boussif and T. Delair and C Brua and Laurent V{\'e}ron and Andr{\'e}a Pavirani and Hilde Kolbe},
  journal={Bioconjugate chemistry},
  year={1999},
  volume={10 5},
  pages={877-83}
}
Cationic polymers possessing primary amine groups are inefficient in transferring nucleic acids into eukaryotic cells. With appropriate chemical modification, namely glycolylation of the amine groups of polylysine and polyallylamine, the actual number of free amino groups was decreased, hydrophilic residues were introduced, and the cytotoxicity of both polymers decreased significantly. Furthermore, in the case of polyallylamine, its ability to mediate gene transfer into cells increased by… CONTINUE READING

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