Synthesis of poly(ethylene glycol)-metaxalone conjugates and study of its controlled release in vitro.

@article{Zhang2007SynthesisOP,
  title={Synthesis of poly(ethylene glycol)-metaxalone conjugates and study of its controlled release in vitro.},
  author={Juan Zhang and Xiaodong Fan and Yifeng Liu and Lan Bo and Xiang Nan Liu},
  journal={International journal of pharmaceutics},
  year={2007},
  volume={332 1-2},
  pages={125-31}
}
Metaxalone (Met), a drug for treatment of pain and stiffness due to muscular injuries, was covalently linked to poly(ethylene glycols) (PEG) via a chloroacetyl chloride spacer. The average weight molecular weights used for PEG are 4000, 6000 and 10,000, respectively, and the procedure of chemical modification for PEGs was conducted by a two-step protocol: (1) synthesis of N-chloroacetyl-metaxalone; (2) synthesis of PEG(4000)-Met, PEG(6000)-Met and PEG(10000)-Met. The controlled drug release… CONTINUE READING