Synthesis of phthalazinones via palladium(II)-catalysed intramolecular oxidative C-H/C-H cross-coupling of N'-methylenebenzohydrazides.

Abstract

A palladium(II)-catalysed intramolecular oxidative C-H/C-H cross-coupling of N'-methylenebenzohydrazides to phthalazin-1(2H)-ones has been developed. This cyclization is believed to mechanistically proceed via electrophilic ortho-palladation and subsequent C-arylation of the carbon-nitrogen double bond. 
DOI: 10.1039/c3ob40195b

Cite this paper

@article{Matsuda2013SynthesisOP, title={Synthesis of phthalazinones via palladium(II)-catalysed intramolecular oxidative C-H/C-H cross-coupling of N'-methylenebenzohydrazides.}, author={Takanori Matsuda and Yuki Tomaru and Yoshinari Matsuda}, journal={Organic & biomolecular chemistry}, year={2013}, volume={11 13}, pages={2084-7} }