Synthesis of phosphorothioate-containing DNA fragments by a modified hydroxybenzotriazole phosphotriester approach.

@article{Marugg1984SynthesisOP,
  title={Synthesis of phosphorothioate-containing DNA fragments by a modified hydroxybenzotriazole phosphotriester approach.},
  author={J. E. Marugg and C J van den Bergh and Marijke Tromp and Gijsbert A. van der Marel and W J van Zoest and Jacques H. van Boom},
  journal={Nucleic acids research},
  year={1984},
  volume={12 23},
  pages={
          9095-110
        }
}
The phosphorothioylating agent which was obtained by treating 2,5-dichlorophenyl phosphorodichloridothioate with 1-hydroxy-6-nitrobenzotriazole proved to be very effective for the synthesis in solution and on a solid support of phosphorothioate-containing DNA fragments. 

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United States Patent ( 19 )

Susan A. Loring, UR SPECIFC, IFIC UREASE
  • 2017