Synthesis of oxazolidinones: rhodium-catalyzed C-H amination of N-mesyloxycarbamates.

  title={Synthesis of oxazolidinones: rhodium-catalyzed C-H amination of N-mesyloxycarbamates.},
  author={H. Lebel and Laura Mamani Laparra and M. Khalifa and C. Trudel and Cl{\'e}ment Audubert and Mathieu Szponarski and C{\'e}dric Dicaire Leduc and Emna Azek and M. Ernzerhof},
  journal={Organic \& biomolecular chemistry},
  volume={15 19},
N-Mesyloxycarbamates undergo intramolecular C-H amination reactions to afford oxazolidinones in good to excellent yields in the presence of rhodium(ii) carboxylate catalysts. The reaction is performed under green conditions and potassium carbonate is used, forming biodegradable potassium mesylate as a reaction by-product. This method enables the production of electron-rich, electron-deficient, aromatic and heteroaromatic oxazolidinones in good to excellent yields. Conformationally restricted… Expand
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