Synthesis of osteotropic hydroxybisphosphonate derivatives of fluoroquinolone antibacterials.

@article{Mcpherson2012SynthesisOO,
  title={Synthesis of osteotropic hydroxybisphosphonate derivatives of fluoroquinolone antibacterials.},
  author={J. Mcpherson and R. Runner and T. Buxton and J. Hartmann and D. Fǎrcaşiu and Ilona Bereczki and E. Rőth and Szilvia Tollas and E. Ostorh{\'a}zi and F. Rozgonyi and P. Herczegh},
  journal={European journal of medicinal chemistry},
  year={2012},
  volume={47 1},
  pages={
          615-8
        }
}
  • J. Mcpherson, R. Runner, +8 authors P. Herczegh
  • Published 2012
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 1-Hydroxybisphosphonate derivatives of ciprofloxacin, gatifloxacin and moxifloxacin have been synthesized using Cu(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction. The 1,2,3-triazol linked hydroxybisphosphonate derivative of ciprofloxacin exhibited antibacterial activity comparable to the parent antibiotic and all fluoroquinolone-bisphosphonates displayed osteotropic properties in a bone model. 
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