Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of the multidrug efflux pump NorA of Staphylococcus aureus.

@article{Vidaillac2007SynthesisOO,
  title={Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of the multidrug efflux pump NorA of Staphylococcus aureus.},
  author={C{\'e}line Vidaillac and Jean Guillon and Corinne Arpin and Isabelle Forfar-Bares and Boubakar B. Ba and Jean Grellet and St{\'e}phane Moreau and D Caignard and Christian Jarry and Claudine Quentin},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 3},
  pages={831-8}
}
A series of 11 pyrrolo[1,2-a]quinoxaline derivatives, 1a to 1k, sharing structural analogies with omeprazole, a eukaryotic efflux pump inhibitor (EPI) used as an antiulcer agent, was synthesized. Their inhibitory effect was evaluated using Staphylococcus aureus strain SA-1199B overexpressing NorA. By determinations of the MIC of norfloxacin in the presence of these EPIs devoid of intrinsic antibacterial activity and used at 128 microg/ml, and by the checkerboard method, compound 1e (MIC… CONTINUE READING

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Antimicrobial combinations, p. 330–396

  • G. M. Eliopoulos
  • 1996
Highly Influential
4 Excerpts

OMEPRAZOLE ANALOGUES AS POTENTIAL NorA INHIBITORS 837 on D ecem er 18, 2017 by gest httpaac.asm .rg/ D ow nladed fom

  • J. Guillon, P. Grellier, M. Labaied, P. Sonnet, J. M. Leger, R. Deprez VOL
  • J. Med. Chem
  • 2007
3 Excerpts

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