Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities.

@article{AbdelAziz2009SynthesisON,
  title={Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities.},
  author={Mohamed Abdel-Aziz and Gamal El-Din A Abuo-Rahma and Alaa Abdulameer Hassan},
  journal={European journal of medicinal chemistry},
  year={2009},
  volume={44 9},
  pages={3480-7}
}
Substituted carboxylic acid hydrazides 1a-d reacted with ethenetetracarbonitril 2 in dimethyl formamide with the formation of diacylhydrazines 4a-d and 5-amino-1-substituted pyrazole-3,3,4-tricarbonitriles 5a-d. On the other hand, 1a-d reacted with diethyl (E)-2,3-dicyanobutenedioate 3 to give oxadiazole derivatives 10a-d and pyrazolone derivatives 11a-d, respectively. The prepared compounds 4a-d, 5a-d and 11a-d were evaluated each for antidepressant activity using tail suspension behavioral… CONTINUE READING