Synthesis of novel estrone analogs by incorporation of thiophenols via conjugate addition to an enone side chain.

@article{Kopel2013SynthesisON,
  title={Synthesis of novel estrone analogs by incorporation of thiophenols via conjugate addition to an enone side chain.},
  author={Lucas C Kopel and Mahmoud S. Ahmed and Fathi T. Halaweish},
  journal={Steroids},
  year={2013},
  volume={78 11},
  pages={1119-25}
}
Functionalized estrogen analogs have received interest due to their unique and differing biological activity compared to their parent compounds. The synthesis of a new class of 3-methoxyestrone analogs functionalized at the C17 position possessing both alkyl and aryl substituted α,β-unsaturated ketones is described, along with their thiophenol conjugate addition products.