Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs.

Abstract

A series of 5-alkylthio (2a-d), 4-arylideneamino (3a-d) and 4-arylideneamino-5-alkylthio derivatives (4a-f) of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole (1) were synthesized by alkylation of the parent compound with alkyl halides and condensation with aldehydes, respectively. Sulfanyl dimers 5a-d and 4-iminomethyl dimer 6 were correspondingly prepared… (More)

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Cite this paper

@article{Wu2007SynthesisON, title={Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs.}, author={Jingde Wu and Xinyong Liu and Xianchao Cheng and Yuan Cao and Defeng Wang and Zhong Li and Wenfang Xu and Christophe Pannecouque and Myriam Witvrouw and Erik de Clercq}, journal={Molecules}, year={2007}, volume={12 8}, pages={2003-16} }