Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents


A novel series of 4,6-diaryl-2-aminopyrimidines 8a–o has been synthesized and evaluated for in vitro antiplasmodial activity against Plasmodium falciparum. Out of the 15 compounds synthesized and tested, 6 compounds have shown IC50 values in the range of 1.61–9.53 μg/mL. These compounds are several times more potent than chloroquine and quinine, the two… (More)
DOI: 10.1007/s00044-012-0328-z

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