Synthesis of new piperazine-pyridazinone derivatives and their binding affinity toward alpha1-, alpha2-adrenergic and 5-HT1A serotoninergic receptors.

Abstract

We report the design and synthesis of a new class of piperazine-pyridazinone analogues. The arylpiperazine moiety, the length of the spacer, and the terminal molecular fragment were varied to evaluate their influence in determining the affinity of the new compounds toward the alpha1-adrenergic receptor (alpha1-AR), alpha2-adrenergic receptor (alpha2-AR… (More)

Topics

Cite this paper

@article{Betti2006SynthesisON, title={Synthesis of new piperazine-pyridazinone derivatives and their binding affinity toward alpha1-, alpha2-adrenergic and 5-HT1A serotoninergic receptors.}, author={Laura Betti and Marco Zanelli and Gino Giannaccini and Fabrizio Manetti and Silvia Schenone and Giovannella Strappaghetti}, journal={Bioorganic & medicinal chemistry}, year={2006}, volume={14 8}, pages={2828-36} }