Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists.
@article{Conti1998SynthesisON, title={Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists.}, author={Paola Conti and Clelia Dallanoce and Marco De Amici and Carlo De Micheli and Karl-Norbert Klotz}, journal={Bioorganic \& medicinal chemistry}, year={1998}, volume={6 4}, pages={ 401-8 } }
A series of delta 2-isoxazoline derivatives structurally related to Broxaterol 1 and Falintolol 3 has been prepared and evaluated for their binding affinity to beta 1- and beta 2-adrenergic receptors. Among the tested compounds only the 3-isopropenyl anti derivative 4d is as active as the reference compounds. An electron-releasing group, probably operating through a pi-pi interaction, in the 3-position of the isoxazoline nucleus greatly enhances the affinity of the compounds. Conversely, the…
2 Citations
Design and Synthesis of New Benzo[d]oxazole-Based Derivatives and Their Neuroprotective Effects on β-Amyloid-Induced PC12 Cells
- Biology, ChemistryMolecules
- 2020
A series of novel synthetic substituted benzo[d]oxazole-based derivatives (5a–5v) exerted neuroprotective effects on β-amyloid (Aβ)-induced PC12 cells as a potential approach for the treatment of…
Analysis of Chemical Compositions of 15 Different Cold-Pressed Oils Produced in Turkey: A Case Study of Tocopherol and Fatty Acid Analysis
- Chemistry
- 2017
Many people tend to prefer natural foods and supplements nowadays. Considering this tendency, this study assessed the most significant in quality and purity parameters tocopherol and fatty acid…