Synthesis of new cyclooxygenase-2 inhibitor:rofecoxib

@inproceedings{Anhui2002SynthesisON,
  title={Synthesis of new cyclooxygenase-2 inhibitor:rofecoxib},
  author={Wu An-hui},
  year={2002}
}
Rofecoxib,a new cyclooxygenase-2 inhibitor was prepared according to a new shorter route.4-(methylsulfonyl)acetophenone(2) which is inexpensive and easily available was used as the starting material,through bromination,condensation and cyclization steps to gain the target compound.The structure of the final compound was confirmed by 1H-NMR, 13 C-NMR and EI-MS.The overall yield was 64%.