Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.

@article{Siracusa2008SynthesisON,
  title={Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.},
  author={M. Siracusa and L. Salerno and M. Modica and V. Pittal{\`a} and G. Romeo and M. Amato and M. Nowak and A. Bojarski and I. Mereghetti and A. Cagnotto and T. Mennini},
  journal={Journal of medicinal chemistry},
  year={2008},
  volume={51 15},
  pages={
          4529-38
        }
}
A series of new compounds containing a benzimidazole, benzothiazole, or benzoxazole nucleus linked to an arylpiperazine by different thioalkyl chains was prepared. They were tested in radioligand binding experiments to evaluate their affinity for 5-HT 1A and 5-HT 2A serotonergic, alpha 1 adrenergic, D1, and D2 dopaminergic receptors. Many of tested compounds showed an interesting binding profile; in particular, 36 displayed very high 5-HT 1A receptor affinity and selectivity over all the other… Expand
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