Synthesis of multilayered alginate microcapsules for the sustained release of fibroblast growth factor-1.

@article{Khanna2010SynthesisOM,
  title={Synthesis of multilayered alginate microcapsules for the sustained release of fibroblast growth factor-1.},
  author={O Khanna and Monica Lizet Moya and Emmanuel C Opara and Eric M. Brey},
  journal={Journal of biomedical materials research. Part A},
  year={2010},
  volume={95 2},
  pages={
          632-40
        }
}
Alginate microcapsules coated with a permselective poly-L-ornithine (PLO) membrane have been investigated for the encapsulation and transplantation of islets as a treatment for type 1 diabetes. The therapeutic potential of this approach could be improved through local stimulation of microvascular networks to meet mass transport demands of the encapsulated cells. Fibroblast growth factor-1 (FGF-1) is a potent angiogenic factor with optimal effect occurring when it is delivered in a sustained… CONTINUE READING
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