Synthesis of mouse renin as a 2-5-33-5 kilodalton pre-pro-two-chain molecule and use of its cDNA to identify the human gene.

@article{Morris1983SynthesisOM,
  title={Synthesis of mouse renin as a 2-5-33-5 kilodalton pre-pro-two-chain molecule and use of its cDNA to identify the human gene.},
  author={Brian J. Morris and D F Catanzaro and John J. Mullins and James Hardman and John Shine},
  journal={Clinical and experimental pharmacology & physiology},
  year={1983},
  volume={10 3},
  pages={293-7}
}
A DNA coding for mouse submandibular gland (MSG) renin was used in studies of the biosynthesis and processing of MSG renin and precursors and as a probe for identification of the human renin gene. A 2 kilodalton signal peptide was demonstrated by cleavage of preprorenin (45 kilodaltons) in the presence of microsomal membranes from dog pancreas. Prior… CONTINUE READING