Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism

@article{Destexhe1994SynthesisOM,
  title={Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism},
  author={Alain Destexhe and Zachary F. Mainen and Terrence J. Sejnowski},
  journal={Journal of Computational Neuroscience},
  year={1994},
  volume={1},
  pages={195-230}
}
Markov kinetic models were used to synthesize a complete description of synaptic transmission, including opening of voltage-dependent channels in the presynaptic terminal, release of neurotransmitter, gating of postsynaptic receptors, and activation of second-messenger systems. These kinetic schemes provide a more general framework for modeling ion channels than the Hodgkin-Huxley formalism, supporting a continuous spectrum of descriptions ranging from the very simple and computationally… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 141 references

Ionic channels: molecular pores of excitable membranes.

Harvey lectures • 1986
View 3 Excerpts
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Sodium conductance ldnetics. Solution of the general, linear three-state model

L Goldman, R Hahin
Cell Biophys • 1979
View 3 Excerpts
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