Synthesis of micheliolide derivatives and their activities against AML progenitor cells.


Micheliolide (MCL) derivatives with etherification or esterification of the hydroxyl group at the C4 position were synthesized and evaluated for their activities against different acute myelogenous leukemia (AML) cell lines. These derivatives demonstrated comparable activities against AML cell lines HL-60 and doxorubicin resistant cell line HL-60/A. As to… (More)
DOI: 10.3390/molecules18055980


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