Synthesis of metronidazole from ethylenediamine

@article{Kraft2004SynthesisOM,
  title={Synthesis of metronidazole from ethylenediamine},
  author={M. Ya. Kraft and P. M. Kochergin and A. M. Tsyganova and V. S. Shlikhunova},
  journal={Pharmaceutical Chemistry Journal},
  year={2004},
  volume={23},
  pages={861-863}
}
We have previously described the preparation of IV from tartaric acid and o-phenylenediamine, whereby the most important intermediate product of the synthesis of IV, 2-methylimidazole (II), was obtained by decarboxylation of 2-methylimidazol-4,5-dicarboxylic acid, the nitration of II was carried out using inorganic nitrates, and the hydroxyethylation of 2-methyl-4(5)-nitroimidazole (III) was effected by means of ethylene chlorohydrin [i, 7, ii]. 
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