• Chemistry
  • Published 2006

Synthesis of methyl pyropheophorbide-αsubstituted at 3-position by alkyl group

@inproceedings{Jinjun2006SynthesisOM,
  title={Synthesis of methyl pyropheophorbide-αsubstituted at 3-position by alkyl group},
  author={Wang Jin-jun},
  year={2006}
}
Methyl pyropheophorbide-α(MPP-α) was used as starting material. The carbonyl group on Ering of methyl pyropheophorbide-d was protected and the Crignard reaction with 1-ethylpropyl magnesium bromide was performed. The sec-alcohol obtained from Crignard reaction was subjected to deprotection, dehydrateion and oxidation to give mew methyl pyropheophorbide-a derivatives. The structures of the compounds were characterized by elemental analysis, UV,IR and H NMR spectra.