Synthesis of long prebiotic oligomers on mineral surfaces

@article{Ferris1996SynthesisOL,
  title={Synthesis of long prebiotic oligomers on mineral surfaces},
  author={James P. Ferris and Aubrey R. Hill and Rihe Liu and Leslie E. Orgel},
  journal={Nature},
  year={1996},
  volume={381},
  pages={59-61}
}
MOST theories of the origin of biological organization assume that polymers with lengths in the range of 30–60 monomers are needed to make a genetic system viable1. But it has not proved possible to synthesize plausibly prebiotic polymers this long by condensation in aqueous solution, because hydrolysis competes with polymerization. The potential of mineral surfaces to facilitate prebiotic polymerization was pointed out long ago2. Here we describe a system that models prebiotic polymerization… Expand
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References

SHOWING 1-9 OF 9 REFERENCES
Template-directed oligonucleotide ligation on hydroxylapatite
TLDR
A sequence of reactions in which initially formed oligo(G)s are reactivated by conversion to phosphorimidazolides in the presence of poly(C) and then allowed to ligate is ideal, in that repeated cycles can be carried out on the surface of hydroxylapatite, whereas in the liquid phase the cycle could be achieved only with considerable difficulty. Expand
Montmorillonite catalysis of RNA oligomer formation in aqueous solution. A model for the prebiotic formation of RNA.
TLDR
It is concluded from the composition of the oligomers that the rate of addition ImpA to a 3'-terminus containing a 2,'5'-linkage is slower than the addition to a nucleoside joined by a 3',5'-linked phosphodiester bond. Expand
N,N'-carbonyldiimidazole-induced peptide formation in aqueous solution.
TLDR
The reaction of N,N′-carbonyldiimidazole with amino acids may provide a convenient method for the synthesis of peptides in aqueous solution and it is believed that N-carboxyanhydrides are involved as intermediates. Expand
Kinetic and mechanistic analysis of dinucleotide and oligonucleotide formation from the 5'-phosphorimidazolide of adenosine on Na(+)-montmorillonite.
TLDR
The catalytic ability of montmorillonite to form din nucleotides and oligonucleotides is quantitatively evaluated and possible pathways for oligo(A) formation are proposed. Expand
ACKNOWLEDGEMENTS. We thank the Amedcam Colloid Co. for a gift of volclay, the mineral from w41_ch the Na" -mocltmonllonite used in thisstudywas pcepared,and G,/Vrhardus
  • chem. Soc
  • 1994
RNA world
The Phys/ca/Bas/s ofUfe (Routledge & Kega_ Paul
  • 1951
The Phys/ca/Bas/s ofUfe (Routledge & Kega_ Paul, London
  • 1951