Synthesis of linear, beta-cyclodextrin-based polymers and their camptothecin conjugates.

@article{Cheng2003SynthesisOL,
  title={Synthesis of linear, beta-cyclodextrin-based polymers and their camptothecin conjugates.},
  author={Jianjun Cheng and Kay T. Khin and Gregory S Jensen and Aijie Liu and Mark E Davis},
  journal={Bioconjugate chemistry},
  year={2003},
  volume={14 5},
  pages={1007-17}
}
6(A),6(D)-Bis-(2-amino-2-carboxylethylthio)-6(A),6(D)-dideoxy-beta-cyclodextrin 1, a diamino acid derivative of beta-cyclodextrin, is synthesized and condensed with difunctionalized PEG comonomers to give linear, high molecular weight (M(w) over 50 kDa) beta-cyclodextrin-based polymers (2-4) with pendant functionality (carboxylate). 2-4 are all highly soluble in aqueous solutions (over 200 mg/mL). 20-O-trifluoroglycinylcamptothecin, 5a, and 20-O-trifluoroglycinylglycinylglycinylcamptothecin, 5b… CONTINUE READING

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