Synthesis of isoprenoid bisphosphonate ethers through C–P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase

@inproceedings{Zhou2014SynthesisOI,
  title={Synthesis of isoprenoid bisphosphonate ethers through C–P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase},
  author={Xiang Zhou and Jacqueline Erin Reilly and Kathleen A Loerch and Raymond J. Hohl and David F Wiemer},
  booktitle={Beilstein journal of organic chemistry},
  year={2014}
}
A set of bisphosphonate ethers has been prepared through sequential phosphonylation and alkylation of monophosphonate ethers. After formation of the corresponding phosphonic acid salts, these compounds were tested for their ability to inhibit the enzyme geranylgeranyl diphosphate synthase (GGDPS). Five of the new compounds show IC50 values of less than 1 μM against GGDPS with little to no activity against the related enzyme farnesyl diphosphate synthase (FDPS). The most active compound… CONTINUE READING

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