Synthesis of indolyl-3-acetonitrile derivatives and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.

@article{Kwon2013SynthesisOI,
  title={Synthesis of indolyl-3-acetonitrile derivatives and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.},
  author={Tae Hoon Kwon and Ik Hwan Yoon and Ji-Sun Shin and Young Hun Lee and Bong Jin Kwon and K. -J. Lee and Yong Sup Lee},
  journal={Bioorganic & medicinal chemistry letters},
  year={2013},
  volume={23 9},
  pages={2571-4}
}
Arvelexin is one of major constituents of Brassica rapa that exerts anti-inflammatory activities. Several indolyl-3-acetonitrile derivatives were synthesized as arvelexin analogs and evaluated for their abilities to inhibit NO and PGE2 productions in LPS-induced RAW 264.7 cells. Of the indolyl-3-acetonitriles synthesized, compound 2k, which possesses a… CONTINUE READING