Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling.

  title={Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling.},
  author={H J Lehmler and Larry W Robertson},
  volume={45 8},
An improved synthesis of hydroxylated polychlorinated biphenyls (PCBs) which are structurally related to the major hydroxy PCB congeners identified in human plasma is described. The coupling of (chlorinated) aryl boronic acids with bromochloro anisoles using the standard conditions of the Suzuki coupling gave the desired hydroxylated PCB metabolites in good to excellent yields. The approach offers the advantage of high selectivity and good yields compared to conventional methods such as the… CONTINUE READING

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