Synthesis of hybrid bisnucleoside 5′, 5‴ — P1, P4 — tetraphosphates by aminoacyl — tRNA synthetases

@article{Traut2004SynthesisOH,
  title={Synthesis of hybrid bisnucleoside 5′, 5‴ — P1, P4 — tetraphosphates by aminoacyl — tRNA synthetases},
  author={T. Traut},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={75},
  pages={15-21}
}
  • T. Traut
  • Published 2004
  • Biology, Medicine
  • Molecular and Cellular Biochemistry
Aminoacyl tRNA synthetases, by means of a back reaction, are able to synthesize certain 5′, 5‴ - P1, P4 — bisnucleoside tetraphosphates of biological importance, such as ANA. Here it is shown that HisRS and TrpRS (Bacillus stearothermophilus) and AlaRS (E. coli) also synthesize the hybrid compounds Ap4G, Ap4C, and Ap4U. GInRS (E. coli) is unable to synthesize any of the above compounds.AlaRS synthesizes Ap4U very poorly, and Ap4C and Ap4G almost as effectively as Ap4A. HisRS and TrpRS… Expand
3 Citations
Enzymatic synthesis of mono and dinucleoside polyphosphates.
Diadenosine tetraphosphate (Ap4A): its presence and functions in biological systems.
  • M. Andersson
  • Biology, Medicine
  • The International journal of biochemistry
  • 1989

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