Synthesis of highly porous crosslinked elastin hydrogels and their interaction with fibroblasts in vitro.

  title={Synthesis of highly porous crosslinked elastin hydrogels and their interaction with fibroblasts in vitro.},
  author={Nasim Annabi and Suzanne M. Mithieux and Elizabeth Anne Boughton and Andrew J. Ruys and Anthony S Weiss and Fariba Dehghani},
  volume={30 27},
In this study the feasibility of using high pressure CO2 to produce porous alpha-elastin hydrogels was investigated. Alpha-elastin was chemically crosslinked with hexamethylene diisocyanate that can react with various functional groups in elastin such as lysine, cysteine, and histidine. High pressure CO2 substantially affected the characteristics of the fabricated hydrogels. The pore size of the hydrogels was enhanced 20-fold when the pressure was increased from 1 bar to 60 bar. The swelling… CONTINUE READING
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