Synthesis of glycosylated tuftsins and tuftsin-containing IgG fragment undecapeptide.

@article{Biondi1991SynthesisOG,
  title={Synthesis of glycosylated tuftsins and tuftsin-containing IgG fragment undecapeptide.},
  author={Laura Biondi and Fernando Filira and Marina Gobbo and Barbara Scolaro and Raniero Rocchi},
  journal={International journal of peptide and protein research},
  year={1991},
  volume={37 2},
  pages={
          112-21
        }
}
Syntheses are described of two new tuftsin derivatives containing a 2-acetamido-2-deoxy-D-galactopyranosyl unit alpha- or beta-glycosidically linked to the threonine's hydroxy side chain function and of the glycosylated undecapeptide corresponding to the tuftsin region of the heavy chain of IgG (amino acid sequence 289-299). The glycosylated tuftsins were synthesized by the solution procedure. Fmoc-[Gal NAc(Ac)3 alpha]Thr-OH and Fmoc-[GalNAc(Ac)3 beta]Thr-OH were allowed to react with H-Lys(Z… Expand
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TLDR
The features of tuftsin, coupled with its low toxicity, make the peptide an attractive candidate for immunotherapy and its capacity to augment cellular activation is mediated by specific receptors that were identified, characterized, and recently isolated from rabbit peritoneal granulocytes. Expand
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