Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells.

@article{Landi2009SynthesisOG,
  title={Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells.},
  author={M. Landi and G. Catelani and F. D'Andrea and E. Ghidini and G. Amari and Puccini Paola and N. Bianchi and R. Gambari},
  journal={European journal of medicinal chemistry},
  year={2009},
  volume={44 2},
  pages={
          745-54
        }
}
  • M. Landi, G. Catelani, +5 authors R. Gambari
  • Published 2009
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • A series of carbamides derived from 1,2:5,6-di-O-isopropylidene-D-gluco- and D-allofuranose as well as their 5,6-O-deprotected analogues (2 and 4) and methyl 3,4-O-isopropylidene-alpha- and beta-D-galactopyranosides (5 and 6) have been prepared in order to evaluate their ability to induce erythroid differentiation of human erythroleukemic K562 cells. Twenty out of 51 carbamides tested exhibit an appreciable activity as inducers of erythroid differentiation and have been fully characterized and… CONTINUE READING
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