Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus.

  title={Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus.},
  author={Angelika Gr{\"u}ndling and Olaf Schneewind},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 20},
Lipoteichoic acid (LTA), a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. However, the molecular basis for its synthesis or function is not known. Here we report that Staphylococcus aureus LtaS synthesizes glycerol phosphate LTA. Construction of a mutant S. aureus strain with inducible ltaS expression revealed that LTA synthesis is required for bacterial growth and cell division. An ltaS homologue of Bacillus subtilis restored LTA synthesis and the… CONTINUE READING
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