Synthesis of glucopyranoside-based ligands for D-myo-inositol 1,4,5-trisphosphate receptors.

@article{Riley2002SynthesisOG,
  title={Synthesis of glucopyranoside-based ligands for D-myo-inositol 1,4,5-trisphosphate receptors.},
  author={A. Riley and D. Jenkins and R. D. Marwood and B. L. Potter},
  journal={Carbohydrate research},
  year={2002},
  volume={337 12},
  pages={
          1067-82
        }
}
  • A. Riley, D. Jenkins, +1 author B. L. Potter
  • Published 2002
  • Chemistry, Medicine
  • Carbohydrate research
  • Adenophostins A and B are naturally occurring glyconucleotides that interact potently with receptors for D-myo-inositol 1,4,5-trisphosphate, an important second messenger molecule in most cell types. Here we describe the design and synthesis of glucopyranoside-based analogues of adenophostin A lacking the adenine component. The key synthetic strategy involves glycosylation of selectively protected alcohols, derived from methyl beta-D-ribofuranoside or 1,4-anhydroerythritol, using glycosyl… CONTINUE READING
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