Synthesis of gamma-glutamylcysteine as a major low-molecular-weight thiol in lactic acid bacteria Leuconostoc spp.

@article{Kim2008SynthesisOG,
  title={Synthesis of gamma-glutamylcysteine as a major low-molecular-weight thiol in lactic acid bacteria Leuconostoc spp.},
  author={Eun-kyoung Kim and C Cha and Y Cho and Y S Cho and Jung-Hye Roe},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={369 4},
  pages={1047-51}
}
Some members of lactic acid bacteria are known to synthesize glutathione (GSH) or to import it from growth medium, whereas others are not. Analysis of the genome sequences of several Leuconostoc spp. indicate the presence of the gene gshA that encodes gamma-glutamylcysteine synthetase, but not the gene gshB encoding glutathione synthetase. We report here that, in cells of Leuconostoc kimchii and Leuconostoc mesenteroides, gamma-glutamylcysteine (gamma-GC) is present in large amount, whereas GSH… CONTINUE READING