Synthesis of galactofuranose-containing acceptor substrates for mycobacterial galactofuranosyltransferases.

@article{Completo2008SynthesisOG,
  title={Synthesis of galactofuranose-containing acceptor substrates for mycobacterial galactofuranosyltransferases.},
  author={Gladys C Completo and Todd L Lowary},
  journal={The Journal of organic chemistry},
  year={2008},
  volume={73 12},
  pages={4513-25}
}
The major structural component of the cell wall in Mycobacterium tuberculosis, infection by which causes tuberculosis, is the mycolyl-arabinogalactan (mAG) complex. This large glycoconjugates has at its core a backbone of approximately 30 D-galactofuranose (Gal(f)) residues that are linked to peptidoglycan by way of a linker disaccharide containing L-rhamnose and 2-acetamido-2-deoxy-D-glucose. Recent studies have supported a model of galactan biosynthesis in which the entire structure is… CONTINUE READING

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