Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes.

Abstract

A transition-metal-free three-component coupling involving N-substituted aziridines, arynes and aldehydes resulting in the formation of trisubstituted N-aryl α-amino epoxides has been demonstrated. The reaction likely proceeds via the highly strained cyclic nitrogen ylide intermediates generated from aziridines and arynes.

DOI: 10.1039/c6cc00057f

Cite this paper

@article{Roy2016SynthesisOF, title={Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes.}, author={Tony Roy and Manikandan Thangaraj and Rajesh G Gonnade and Akkattu T Biju}, journal={Chemical communications}, year={2016}, volume={52 58}, pages={9044-7} }