Synthesis of dinitrophenyl-L-Pro-N-hydroxysuccinimide ester and four new variants of Sanger's reagent having chiral amines and their application for enantioresolution of mexiletine using reversed-phase high-performance liquid chromatography.

@article{Bhushan2009SynthesisOD,
  title={Synthesis of dinitrophenyl-L-Pro-N-hydroxysuccinimide ester and four new variants of Sanger's reagent having chiral amines and their application for enantioresolution of mexiletine using reversed-phase high-performance liquid chromatography.},
  author={R. Bhushan and Shivani Tanwar},
  journal={Journal of chromatography. A},
  year={2009},
  volume={1216 30},
  pages={
          5769-73
        }
}
  • R. Bhushan, Shivani Tanwar
  • Published 2009
  • Chemistry, Medicine
  • Journal of chromatography. A
  • Four chiral derivatizing reagents (CDRs) having enantiomerically pure amines and two CDRs namely, [N-succinimidyl-(S)-2-(6-methoxynaphth-2-yl)propionate], and [dinitrophenyl-L-Pro-N-hydroxysuccinimide ester, DNP-L-Pro-SU] were synthesized and were used to prepare diastereomers of (R,S)-mexiletine (MEX); these were separated by reversed-phase high-performance liquid chromatography (RP-HPLC). The method was validated for linearity, accuracy, limit of detection (LOD) and limit of quantification… CONTINUE READING
    16 Citations

    Figures, Tables, and Topics from this paper

    Indirect reversed-phase high-performance liquid chromatographic and direct thin-layer chromatographic enantioresolution of (R,S)-Cinacalcet.
    • 16

    References

    SHOWING 1-10 OF 25 REFERENCES