Synthesis of erythromycin derivatives via the olefin cross-metathesis reaction.

Abstract

Olefin cross metathesis (CM) was applied to the synthesis of 6-O-substituted erythromycin derivatives. The reactions were catalyzed by transition metal alkylidene complexes, particularly bis(tricyclohexylphosphine)benzylidine ruthenium (IV) dichloride (Grubbs' first-generation catalyst). This approach allowed for the elaboration of the 6-O-allyl group of… (More)

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@article{Hsu2004SynthesisOE, title={Synthesis of erythromycin derivatives via the olefin cross-metathesis reaction.}, author={Margaret C Hsu and Adam J Junia and Anthony R. Haight and Weijiang Zhang}, journal={The Journal of organic chemistry}, year={2004}, volume={69 11}, pages={3907-11} }