Synthesis of enzymatically-gellable carboxymethylcellulose for biomedical applications.

  title={Synthesis of enzymatically-gellable carboxymethylcellulose for biomedical applications.},
  author={Yuko Ogushi and Shinji Sakai and Koei Kawakami},
  journal={Journal of bioscience and bioengineering},
  volume={104 1},
We synthesized a carboxymethylcellulose with phenol moieties by covalently incorporating tyramine into carboxymethylcellulose using aqueous-phase carbodiimide activation chemistry. The resulting hydrogel was obtained from an aqueous solution of the conjugate via the horseradish peroxidase-catalyzed oxidation reaction of phenols by consuming H(2)O(2), where the gelation speed depended on the concentrations of enzyme and H(2)O(2). The viability of the mammalian cells enclosed within the hydrogel… CONTINUE READING

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