Synthesis of enkephalinase B inhibitors, and their activity on isolated enkephalin-degrading enzymes.

Abstract

Compounds in which a dipeptide moiety is linked to a metal chelating mercapto group were synthesized to obtain effective enkephalinase B inhibitors. Inhibitors containing two hydrophobic amino acid side-chains decrease enkephalinase B activity with a potency depending on the length of the spacer connecting the mercapto group and the dipeptide (IC50 values… (More)

Topics

Cite this paper

@article{Amsterdam1987SynthesisOE, title={Synthesis of enkephalinase B inhibitors, and their activity on isolated enkephalin-degrading enzymes.}, author={Jan G. C. van Amsterdam and K J van Buuren and M W Blad and Willem Soudijn}, journal={European journal of pharmacology}, year={1987}, volume={135 3}, pages={411-8} }