Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions.

  title={Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions.},
  author={Eva J. Gordon and Jason E. Gestwicki and Laura E. Strong and Laura L Kiessling},
  journal={Chemistry & biology},
  volume={7 1},
BACKGROUND Ring-opening metathesis polymerization (ROMP) is a powerful synthetic method for generating unique materials. The functional group tolerance of ruthenium ROMP initiators allows the synthesis of a wide range of biologically active polymers. We generated multivalent ligands that inhibit cell surface L-selectin, a protein that mediates lymphocyte homing and leukocyte recruitment in inflammation. We hypothesized that these ligands function through specific, multivalent binding to L… CONTINUE READING
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