Synthesis of dl-tryptophan by modified broad specificity amino acid racemase from Pseudomonas putida IFO 12996

@article{Kino2006SynthesisOD,
  title={Synthesis of dl-tryptophan by modified broad specificity amino acid racemase from Pseudomonas putida IFO 12996},
  author={Kuniki Kino and Masaru Sato and Mariko Yoneyama and Kohtaro Kirimura},
  journal={Applied Microbiology and Biotechnology},
  year={2006},
  volume={73},
  pages={1299-1305}
}
Broad specificity amino acid racemase (E.C. 5.1.1.10) from Pseudomonas putida IFO 12996 (BAR) is a unique racemase because of its broad substrate specificity. BAR has been considered as a possible catalyst which directly converts inexpensive l-amino acids to dl-amino acid racemates. The gene encoding BAR was cloned to utilize BAR for the synthesis of d-amino acids, especially d-Trp which is an important intermediate of pharmaceuticals. The substrate specificity of cloned BAR covered all of the… CONTINUE READING

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