Synthesis of fatty trichloromethyl-β-diketones and new 1H−pyrazoles as unusual FAMEs and FAEEs
- AFC Flores, RF Blanco, AA Souto, JL Malavolta, DC Flores
- J Braz Chem Soc 24:2059–2065
An elegant, efficient, and highly regioselective approach for the synthesis of novel methyl 5-amino-3-(methylthio)-1-differently substituted-1H-pyrazole-4-carboxylates is reported. The procedure involves the cyclocondensation of $$\alpha $$ α -oxeketene $$S,S$$ S , S -dimethyl acetal building blocks with different alkyl, aryl, and heterocyclic acid hydrazides. The novel molecules were obtained in good yields and their identities confirmed by NMR and HRMS spectrometry.