Synthesis of diverse N-acyl-pyrazoles via cyclocondensation of hydrazides with $$\alpha $$ α -oxeketene dithioacetal

Abstract

An elegant, efficient, and highly regioselective approach for the synthesis of novel methyl 5-amino-3-(methylthio)-1-differently substituted-1H-pyrazole-4-carboxylates is reported. The procedure involves the cyclocondensation of $$\alpha $$ α -oxeketene $$S,S$$ S , S -dimethyl acetal building blocks with different alkyl, aryl, and heterocyclic acid hydrazides. The novel molecules were obtained in good yields and their identities confirmed by NMR and HRMS spectrometry.

DOI: 10.1007/s11030-017-9771-6

Cite this paper

@article{Pereira2017SynthesisOD, title={Synthesis of diverse N-acyl-pyrazoles via cyclocondensation of hydrazides with \$\$\alpha \$\$ α -oxeketene dithioacetal}, author={Bruna {\'A}vila Pereira and Alcione V. de Bastos and Wystan Kreisly Othon Teixeira and Sidnei Moura e Silva and Alex Fabiani Claro Flores and Darlene Correia Flores}, journal={Molecular Diversity}, year={2017}, volume={21}, pages={1021-1026} }