Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents.

@article{Dwivedi2007SynthesisOD,
  title={Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents.},
  author={Anil Kumar Dwivedi and Vishnu Lal Sharma and Niharika Kumaria and Singarapu Kiran Kumar and Pradeep Kumar Srivastava and Abdul W M H Ansari and Jagdamba Prasad Maikhuri and Gopal N. Gupta and Janak Dulari Dhar and Raja Roy and Bhawani Shankar Joshi and Praveen Kumar Shukla and Manish Kumar and Satyawan Singh},
  journal={Bioorganic & medicinal chemistry},
  year={2007},
  volume={15 21},
  pages={6642-8}
}
S,S'-[disulfanediylbis(dialkylaminopropane-2,1-diyl)]bis- (dialkylaminothiocarbamate) (14-31) were prepared and evaluated for the spermicidal activity and antifungal activity. Dialkyldithiocarbamates (1-5) were reacted with epichlorohydrin to give 1-dialkylaminocarbothioic acid S-[(2,3-epithio)propyl]ester (7-11), these on further reaction with a secondary amine gave S,S'-[disulfanediylbis(dialkylaminopropane-2,1-diyl)]bis- (dialkylaminothiocarbamate) (14-31). Some of these compounds (16, 19-21… CONTINUE READING