Synthesis of dinucleoside phosphorodithioates from nucleoside phosphonodithioates.

Abstract

The conversion, in good yield, of 5'-O-(9-phenylxanthen-9-yl) thymidine (1) into the triethylammonium salt of its 3'-phosphonodithioate (2a) is described. The latter compound (2a) is converted into a dinucleoside phosphonothioate (4a), and thence into a corresponding dinucleoside phosphorodithioate (6a) and phosphorothioate (6;X = 0).

Cite this paper

@article{Porritt1989SynthesisOD, title={Synthesis of dinucleoside phosphorodithioates from nucleoside phosphonodithioates.}, author={G M Porritt and Colin B. Reese}, journal={Nucleic acids symposium series}, year={1989}, volume={21}, pages={55-6} }