Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase.

@article{Gangjee1999SynthesisOC,
  title={Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase.},
  author={Aleem Gangjee and Farahnaz Mavandadi and Roy L. Kisliuk and Sherry F. Queener},
  journal={Journal of medicinal chemistry},
  year={1999},
  volume={42 12},
  pages={2272-9}
}
Compounds 2-5 were designed as potential antifolate nonpolyglutamatable inhibitors of thymidylate synthase (TS). These analogues are structurally related to 2-amino-4-oxo-5-substituted quinazolines and 2-amino-4-oxo-5-substituted pyrrolo[2, 3-d]pyrimidines which have shown excellent inhibition of TS and, for the quinazoline, significant promise as… CONTINUE READING