Synthesis of chiral N-heterocyclic carbene ligands with rigid backbones and application to the palladium-catalyzed enantioselective intramolecular α-arylation of amides.

@article{Liu2011SynthesisOC,
  title={Synthesis of chiral N-heterocyclic carbene ligands with rigid backbones and application to the palladium-catalyzed enantioselective intramolecular α-arylation of amides.},
  author={Lantao Liu and Naoki Ishida and Shinji Ashida and Masahiro Murakami},
  journal={Organic letters},
  year={2011},
  volume={13 7},
  pages={1666-9}
}
Chiral N-heterocyclic carbene (NHC) ligands having a 2,2'-bisquinoline-based C(2) symmetric skeleton were developed. The ligands exhibited good enantioselectivity in palladium-catalyzed intramolecular α-arylation of amides to give 3,3-disubsituted oxindoles. 

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